Figure 5.

Predicting R_h from intrinsic PP_II propensities and net charge. A) Filled circles show R_h (in Å) predicted from sequence for each dataset IDP using equation 6. The identity line is shown by the stippled line. Inset: slope and y-intercept for the linear trend in Fig. 4C when a singular IDP is removed from the training set. B) Each filled circle represents the removal of a singular IDP from the training set. The concomitant change in correlation for predicted and experimental R_h (ΔR²) is compared to the fractional change in predicted R_h for the removed IDP. C) Prediction error, normalized for IDP size by equation 5, was compared to 567 amino acid scales (same scales as Fig. 4B). The correlation (R²) for each comparison is in rank order from left to right. Inset: Number of amino acids scales with R² greater than the average plus 3, 4, and 5 times the standard deviation (σ). D) Comparison of prediction error to the best performing scale, normalized frequency of α helix in all α class,¹⁰⁴ showing the trend line.