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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Hepatology. 2016 Dec 24;65(2):616–630. doi: 10.1002/hep.28912

Figure 6. Increased expression of lipolytic genes in NR treated mice.

Figure 6

10–14 week old male C57BL6/J mice were treated with NR at a dose of ~500mg/kg/day. After 2 weeks, mice were subjected to 2/3 partial hepatectomy. Hepatic gene expression was determined either pre PHx or 24h post PHx.

(A) Expression of genes related to the unfolded protein response in the mitochondria (UPRmito) or endoplasmic reticulum (UPRer), or to mitochondrial biogenesis.

(B) Expression of genes related to lipid metabolism.

Expression of Atgl, Hsl, Mcad, Acox1, Fasn, Srebp1c, Acc1, Acc2, Atf4, Xbp1m, Hspd1, Atp5a1, Sdhb and Cox5b were significantly different (p < 0.05) in regenerating liver as compared to pre-PHx livers.

Error bars represent S.E.M. #, p < 0.1; *, p < 0.05; **, p < 0.01; ***, p < 0.001.