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. Author manuscript; available in PMC: 2018 Jan 23.
Published in final edited form as: Integr Biol (Camb). 2017 Jan 23;9(1):6–21. doi: 10.1039/c6ib00178e

Fig. 1. Dynamic microenvironments expand observability space to facilitate investigation of complex network structures.

Fig. 1

A. Dynamic signaling input patterns observed in biological systems including modulation in amplitude, duration, gradient, pulse frequency, and sinusoidal rhythms. B. Examples of network motifs present in transcription networks that can sense temporal inputs. C. Temporal modulation expands the observability space by providing additional input-output responses and aids in distinguishing different network motifs.