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. Author manuscript; available in PMC: 2018 Jan 23.
Published in final edited form as: Integr Biol (Camb). 2017 Jan 23;9(1):6–21. doi: 10.1039/c6ib00178e

Fig. 3. Mechanistic insights provided by pulsatile stimulation and mathematical modeling.

Fig. 3

A. Several circuit architectures can be dissected through frequency response analysis; B. Temporal encoding/decoding of the downstream response can be uniquely discerned using this approach. C Pulsatile stimulation may also lead to distinct downstream responses, thus regulating different fates through the same input. D. Using microfluidics to study behavior of entrained/phase-locked cells also provides a platform to study collective population behavior often observed physiologically.