Table 3.

Comparison of biochemical parameters between 89 MIS and 89 LIS subjects. Values are real means ± Standard Deviations.

	More insulin sensitive (n=89)	Less insulin sensitive (n=89)	p-value
SHBG (nmol/l)	28.4 ± 1.0	21.8 ± 1.1	< 0.001*
Total Testosterone (pmol/l) (TT)	639.1 ± 18.9	558.9 ± 19.6	0.009*
Free testosterone (pg/ml) (FT)	11.16 ± 0.33	11.32 ± 0.34	0.769
Bio-av testosterone (ng/l) (bio-av T)	272.2 ± 7.8	277.63 ± 8.1	0.666
Total estradiol (pg/ml) (TE2)	23.21 ± 0.8	22.35 ± 0.8	0.470
Free estradiol (nmol/l) (FE2)	0.39 ± 0.02	0.42 ± 0.02	0.216
Bio-av estradiol (pmol/l) (bio-av E2)	15.94 ± 0.62	17.16 ± 0.63	0.181
Log Leptin	0.464 ± 0.03	0.880 ± 0.03	< 0.001*
Vitamin 25(OH)D (ng/ml)	22.36 ± 1.0	18.6 ± 1.1	0.024
Creatinine in Serum (mg/dl)	0.949 ± 0.014	0.916 ± 0.015	0.160
Creatinine in Urine (mg/dl)	182.43 ± 8.6	193.58 ± 8.9	0.423
IGF-1 (nmol/l)	35.32 ± 1.15	45.52 ± 1.16	< 0.001*
IGFBP-3 (ng/ml)	3626.26 ± 52.40	4056.07 ± 52.02	< 0.001*

All biochemical parameters except estradiol and leptin levels were corrected for age, physical activity and fat mass. Estradiol related parameters and leptin were corrected for age and physical activity as fat mass is the main source of these parameters.

^*Significant at p<0.05 level.