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. 2017 Jan 10;2017:2767484. doi: 10.1155/2017/2767484

Figure 1.

Figure 1

H19 is highly expressed in CRC tissues and promotes cell proliferation. (a) H19 expression is significantly increased in CRC tissues compared with adjacent normal tissues, as demonstrated by RT-PCR. ((b) and (c)) H19 overexpression increases the colony formation rate of HCT116 and SW480 cells (soft-agar assay, P < 0.01). (d) H19 overexpression increases the colony formation rate of HCT116 and SW480 cells (plate colony formation assays, P < 0.01). ((e) and (f)) H19 knockdown decreases the colony formation rate of HCT116 and SW480 cells (soft-agar assay, P < 0.01). (g) H19 knockdown decreases the colony formation rate of HCT116 and SW480 cells (plate colony formation assays, P < 0.01). ((h) and (i)) H19 overexpression promotes HCT116 cell proliferation (cell growth curve and cell viability assay, P < 0.05). ((j) and (k)) H19 overexpression promotes SW480 cell proliferation (cell growth curve and cell viability assay, P < 0.05). ((l) and (m)) H19 knockdown inhibits HCT116 cell proliferation (cell growth curve and cell viability assay, P < 0.05). ((n) and (o)) H19 knockdown inhibits SW480 cell proliferation (cell growth curve and cell viability assay, P < 0.05). “∗∗” refers to P < 0.01.