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. 2016 Dec 23;31(1):149–157. doi: 10.1111/jvim.14632

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Copyright © 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Light micrographs of paraffin sections of the cerebral cortex external granular layer from the neuronal ceroid lipofuscinosis‐affected Cane Corso (A and C) and from an age‐matched normal Beagle (B and D). A and B were stained with hematoxylin and eosin. C and D were immunostained with an anti‐GFAP antibody. The diseased dog exhibited a substantial reduction in cell density in the external granular layer and substantial numbers of GFAP‐labeled astrocytes that were not observed in the control dog sample. Bar in (D) indicates magnification of all micrographs.