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The role of PDGFs ligands (PDGF-AB, PDGF-BB, and PDGF-CC) in colorectal carcinogenesis. Although all three ligands are related to colorectal tissues tumors, only PDGF-AB and PDGF-CC present increased blood levels correlated with tumor stages. An increased level of PDGF-BB is correlated to colorectal tumor angiogenesis, while increasing levels of PDGF-AB and PDGF-CC are closely related to invasion and metastasis.
