Table 3.
Food intake; body, liver, and adipose tissue masses; and fasting plasma concentrations of lipids, leptin, and inflammatory markers in NTg and apoCIII mice fed either a low-fat diet (LFD) or a high-fat diet (HFD) for 16 weeks.
| LFD | HFD | |||
|---|---|---|---|---|
| NTg | CIII | NTg | CIII | |
| Food intake (kcal/mouse/day) | 15.41 ± 1.2 | 14.6 ± 0.9 | 19.6 ± 0.8∗ | 21.8 ± 0.6∗ |
| (7) | (7) | (5) | (5) | |
| Body mass (g) | 23.2 ± 0.3 | 24.0 ± 0.3 | 29.6 ± 1.1∗ | 29.5 ± 0.9∗ |
| (17) | (16) | (8) | (6) | |
| Liver (%body weight) | 3.7 ± 0.0 | 3.8 ± 0.1 | 2.9 ± 0.1∗ | 3.2 ± 0.1∗ |
| (17) | (17) | (8) | (8) | |
| Perigonadal WAT (%) | 1.2 ± 0.1 | 1.4 ± 0.1 | 3.0 ± 0.2∗ | 3.6 ± 0.1∗# |
| (10) | (10) | (8) | (8) | |
| Plasma triglycerides (mg/dL) | 71.4 ± 5.0 | 780.2 ± 53.6# | 81.5 ± 3.8 | 668.1 ± 52.8# |
| (7) | (7) | (7) | (7) | |
| Plasma cholesterol (mg/dL) | 122.0 ± 7.8 | 150.3 ± 11.3 | 135.1 ± 4.9 | 199.5 ± 13.2# |
| (9) | (7) | (7) | (8) | |
| Nonesterified fatty acids (mEq/L) | 0.24 ± 0.01 | 0.50 ± 0.04# | 0.30 ± 0.03 | 0.41 ± 0.02# |
| (10) | (8) | (6) | (5) | |
| Plasma leptin (pg/mL) | 635.6 ± 156 | 526.0 ± 162 | 1712.8 ± 618∗ | 3033.4 ± 925∗ |
| (9) | (7) | (6) | (7) | |
| Plasma IL6 (pg/mL) | 5.7 ± 0.6 | 6.5 ± 0.9 | 13.4 ± 0.9∗ | 21.03 ± 2.1∗# |
| (6) | (6) | (7) | (4) | |
| Plasma C-reactive protein (ng/mL) | 320.9 ± 31.2 | 563.1 ± 73.8# | 405.7 ± 45.8 | 628.6 ± 39.7# |
| (9) | (7) | (7) | (8) | |
Mean ± SEM (n). ∗LFD versus HFD groups; #NTg versus apoCIII mice (p < 0.05; two-way ANOVA).