Table 4.
Food intake; body, liver, and adipose tissue masses; and fasting plasma concentrations of lipids and leptin in NTg and CIII mice fed a high-fat diet (HFD) and treated or not with fenofibrate (HFD/F).
| HFD | HFD/F | |||
|---|---|---|---|---|
| NTg | CIII | NTg | CIII | |
| Food intake (kcal/animal/day) | 19.6 ± 0.8 | 20.8 ± 0.6 | 20.1 ± 0.7 | 20.1 ± 0.8 |
| (5) | (5) | (4) | (4) | |
| Body weight (g) | 28.8 ± 0.5 | 31.6 ± 2.2 | 27.4 ± 0.8$ | 28.2 ± 0.3$ |
| (9) | (6) | (6) | (6) | |
| Liver (% body weight) | 3.2 ± 0.1 | 3.0 ± 0.1# | 3.6 ± 0.1$ | 3.4 ± 0.1#$ |
| (7) | (8) | (6) | (6) | |
| Perigonadal WAT (%) | 3.0 ± 0.3 | 3.5 ± 0.3 | 1.8 ± 0.2$ | 2.1 ± 0.4$ |
| (6) | (7) | (6) | (6) | |
| Plasma triglycerides (mg/dL) | 83.2 ± 4.9 | 693.0 ± 28.3# | 59.0 ± 4.7 | 508 ± 59.6# |
| (7) | (7) | (7) | (7) | |
| Plasma cholesterol (mg/dL) | 132.9 ± 5.2 | 187.2 ± 14.2# | 154.3 ± 11.6 | 232.7 ± 30.6# |
| (6) | (6) | (6) | (6) | |
| Nonesterified fatty acids (mEq/L) | 0.33 ± 0.03 | 0.40 ± 0.01# | 0.25 ± 0.02 | 0.48 ± 0.05# |
| (7) | (8) | (6) | (6) | |
| Plasma leptin (pg/mL) | 1783.4 ± 143 | 2011.5 ± 266 | 644.69 ± 57$ | 704.1 ± 52$ |
| (6) | (5) | (6) | (6) | |
Mean ± SEM (n). $HFD versus HFD/F groups; #NTg versus apoCIII mice (p < 0.05; two-way ANOVA).