Table 1.
Family History of venous thromboembolic events of the index case.
| Relationship | Age at diagnosis | Type of AT deficiency | Other inherited or acquired risk factors | History of VTE | Management | Outcome |
|---|---|---|---|---|---|---|
| Mother | 50 | 1 | Smoking | DVT-PE | N/A | VTE resolved |
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| Sister 1 | 18 | 1 | Postpartum at time of death | Fatal PE | N/A | Fatal |
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| Sister 2 | 25 | 1 | Pregnant at time of VTE | Cerebral vein thrombosis | LMWH + AT concentrate | VTE resolved, successful delivery at 34 weeks |
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| Index case | 22 | 1 | None | DVT & PE at age of 25 |
Warfarin until age of 36 |
Developed amaurosis fugax, switched to rivaroxaban |
| DVT during pregnancy at age 37 | Initially on tinzaparin (for pregnancy) but switched to dalteparin and AT concentrate | Miscarriage at GW 7, received D & C after which continued warfarin and AT concentrate × 6 weeks | ||||
AT: antithrombin, D & C: dilatation and curettage, DVT: deep vein thrombosis, gw: gestational week, LMWH: low molecular weight heparin, and PE: pulmonary embolus.