Table 3.
Thrombosis medical profile and antepartum prophylactic use of AT concentrate in pregnant patients with hereditary antithrombin deficiency.
| Study | Study design | Number of cases | Prophylactic condition and numbers of cases | Dosage of AT used | Concurrent anticoagulation | AT concentrate initiation/duration | Goal of AT levels | Outcome | |
|---|---|---|---|---|---|---|---|---|---|
| Primary | Secondary | ||||||||
| Ilonczai et al. 2015 |
Retrospective | 4 | 2 | 2 | 1000–2500 2tw-3tw |
LMWH | Primary, gw 11–28; gw 20–36 Secondary, gw 6–13; gw 25–29 |
80–120% | Miscarriage gw 28 Healthy M and N Miscarriage gw 3 Healthy M and N |
|
| |||||||||
| Rogenhofer et al. (2014) | Retrospective | 4 | 1 | 3 | 1000 2tw- 2500 IU 3tw |
LMWH | Primary, 3 days as initiation of LMWH at early pregnancy to delivery Secondary, gw 6, 7, 34 to delivery |
N/A | Healthy M and N |
|
| |||||||||
| Pascual et al. (2014) |
Case report | 1 | — | 1 | 3000 IU 3tw |
LMWH, UFH then warfarin at 14 wk | gw 4–15 and 11 days peripartum | >50% | Healthy M and N |
|
| |||||||||
| Yamada et al. (2001) |
Case report | 1 | — | 1 | 3000–6000 IU weekly |
N/A | gw 5–38 | 80–90% | Healthy M and N |
AT: antithrombin, gw: gestational week, IU: international units, LMWH: low molecular weight heparin, M: mother, N/A: not available or not specified, N: newborn, UFH: unfractionated heparin, gw: gestational week, IU: international units, IVC: inferior vena cava, UFH: unfractionated heparin, 2tw: two times per week, and 3tw: three times per week.