Table 4. Spearman-Brown rank correlations between Ne/ERN amplitudes and clinical/psychological characteristics in patients with Parkinson’s disease (PD) and healthy controls (HC).
| HC (N = 13) |
PD (N = 13) |
|||
|---|---|---|---|---|
| off | on | off | on | |
| disease duration | — | — | 0.609* | 0.160 |
| LEDD | — | — | 0.220 | 0.148 |
| age | 0.105 | 0.074 | 0.609* | 0.412 |
| education | −0.055 | 0.114 | −0.391 | −0.173 |
| cognitive status (MoCA) | −0.495 | −0.225 | −0.155 | −0.293 |
| apathy (AES) | −0.207 | −0.190 | 0.675* | 0.694** |
| depression (BDI-II) | −0.504 | −0.342 | 0.623* | 0.421 |
| psychiatric status (BSI-18) | −0.243 | −0.047 | 0.743** | 0.532 |
| health status (SF-36) | 0.315 | −0.063 | −0.764** | −0.409 |
| impulsiveness (BIS-Brief) | 0.003 | −0.136 | 0.556* | 0.415 |
| functional impulsivity (DII functional) | 0.192 | 0.070 | −0.502 | −0.161 |
| dysfunctional impulsivity (DII dysfunctional) | −0.114 | −0.342 | 0.469 | 0.363 |
| impulse control (QUIP-RS) | 0.400 | 0.500 | 0.573 | 0.406 |
| impulse control (QUIP-RS impulse control disorder) | 0.386 | 0.463 | 0.602* | 0.384 |
| schizotypal traits (SPQ) | −0.250 | 0.071 | 0.631* | 0.222 |
Note. Positive correlations indicate that higher scores on the respective measure are associated with less negative (i.e., smaller) Ne/ERN amplitudes. Negative correlations indicate that higher scores on the respective measure are associated with more negative (i.e., larger) Ne/ERN amplitudes. Bold typeface indicates significant differences of correlation coefficients between PD and HC (p < 0.05). For PD patients, the conditions “off” and “on” indicate the actual medication state (i.e., whether the patients had taken their usual dose of medication [on] or were tested after withdrawal from dopaminergic medication [off]). The HC group was not administered with dopaminergic medication at any time, and the conditions “off” and “on” were merely used to assign control participants to one of two possible orders of medication conditions (see Methods for detailed explanation). LEDD = levodopa equivalent daily dose, calculated using the conversion factors by ref. 24; MoCA = Montreal Cognitive Assessment22; WST = Wortschatztest27; AES = Apathy Evaluation Scale63; BDI-II = Beck Depression Inventory-II64; BSI-18 = Brief Symptom Inventory (18-item version)65; SF-36 = Short Form Health Survey66; BIS-Brief = Barratt Impulsiveness Scale (8-item version)67; DII = Dickman Impulsivity Inventory68; QUIP-RS = Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease—Rating Scale69; SPQ = Schizotypal Personality Questionnaire70.
*p < 0.05, **p < 0.01.