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. 2017 Jan 24;7:41136. doi: 10.1038/srep41136

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Copyright © 2017, The Author(s)

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(a) Reactive oxygen species (ROS) relative level in renal tubules; and ATP relative level in renal tubular mitochondria. (b) The expression of total Akt protein in each group was at the same level, while p-Akt was significantly lower in the RM group compared with that of the sham group, and p-Akt was significantly upregulated in the RM + BM + MSCs group compared with that of the RM group. Bad, Cytochrome c, cleaved caspase-9, and cleaved caspase-3 were significantly higher in the RM group than in the sham group. MSC treatment significantly reduced Bad, Cytochrome c, cleaved caspase-9, and cleaved caspase-3 compared with the RM group. Bcl-xl was significantly lower in the RM group compared with the sham group, and Bcl-xlwas significantly upregulated in the RM + BM + MSCs group compared with the RM group. Note: *p < 0.05 versus the sham group, ^#p < 0.05 versus the RM group, n = 6.