Figure 2. Manhattan plot showing the significance (−log10(p-value)) of association of non-synonymous variants with PD status.
The horizontal line indicates the Bonferroni multiple testing correction threshold at p = 2.4 × 10−6. Amongst the black points, the blue and green points represent the significance of association for non-synonymous variants within genes involved in the familial form of PD (blue) or genes harboured in one of 26 published PD GWA intervals (green), respectively. The names of genes are given in the top part of plot in blue and green for mono and GWA genes respectively. For 26 GWA intervals, only the name of the gene(s) that possesses the most significant association from the exome non-synonymous variants is showed.