Table 1. Serum levels of proinflammatory cytokines.
| Conc. (pg/ml) | Day 14 |
Day 36 |
||||||
|---|---|---|---|---|---|---|---|---|
| WT + saline | NLRP3 KO + saline | WT + IgAN | NLRP3 KO + IgAN | WT + saline | NLRP3 KO + saline | WT + IgAN | NLRP3 KO + IgAN | |
| IL-1β | 103.3 ± 7.2 | 110.6 ± 4.3 | 154.4 ± 5.2‡‡‡ | 106.7 ± 8.8*** | 107.4 ± 2.4 | 106.8 ± 3.0 | 183.5 ± 3.8‡‡‡ | 113.1 ± 9.5*** |
| TNF-α | 121.0 ± 5.8 | 118.7 ± 4.8 | 196.8 ± 26.1‡‡ | 163.6 ± 14.1‡ | 116.0 ± 13.4 | 120.0 ± 2.7 | 385.0 ± 80.5‡‡‡ | 193.5 ± 14.7‡‡* |
| IL-17A | 6.2 ± 0.8 | 6.2 ± 0.7 | 6.1 ± 0.5 | 6.2 ± 0.9 | 6.0 ± 0.7 | 6.0 ± 0.5 | 18.9 ± 1.7‡‡ | 5.0 ± 0.2*** |
| IL-4 | 3.3 ± 0.2 | 3.1 ± 0.3 | 3.2 ± 0.3 | 3.2 ± 0.2 | 3.2 ± 0.3 | 3.1 ± 0.5 | 3.3 ± 0.4 | 6.7 ± 0.6‡‡** |
| IFN-γ | 5.0 ± 0.8 | 5.3 ± 0.7 | 8.6 ± 1.6 | 6.3 ± 0.7 | 5.1 ± 0.4 | 6.3 ± 0.1 | 16.8 ± 5.1‡ | 5.2 ± 1.8 |
ELISA with serum samples taken from the mice on days 14 and 36 after the induction of IgAN (WT + IgAN mice; NLRP3 KO + IgAN mice) and respective saline controls (WT + saline mice; NLRP3 KO + saline mice). The data are expressed as the mean ± SEM for 7 mice per group. *p < 0.05, **p < 0.01, ***p < 0.005 compared to wild type mice. ‡p < 0.05, ‡‡p < 0.01, ‡‡‡p < 0.005 compared to saline control mice. WT, wild type.