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. 2017 Jan 24;7:41233. doi: 10.1038/srep41233

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Representative tumor burden (total weight, black columns) of MMTV-PyMT(+) mice (n = 10) and mammary glands (red columns) of their wild type PyMT(−) age-matched littermates (n = 10). The values of pO₂ (b), pH_e (c) and [Pi] (d) measured in tissue environment of normal mammary gland (MG, n = 23) and tumor TME (T, n = 18). Error bars are SD. *p = 0.065, **p = 0.006, ***p = 6 × 10⁻⁶.