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. 2017 Jan 24;7:41233. doi: 10.1038/srep41233

Figure 7. Correlation between tumor volume (TV) and interstitial pO2, pHe and [Pi] values measured in the TME of non-metastatic PC14 (n = 12) and metastatic PC14HM (n = 12) tumor xenografts.

Figure 7

(a) Significant correlation was found between pO2 and tumor volume for PC14HM xenografts (r = −0.59, p = 0.045 for PC14HM xenografts; r = −0.44, p = 0.15 for PC14 xenografts and r = −0.5, p = 0.014 for total set of data). (b) No significant correlation was found between pHe and tumor volume (r = 0.02, p = 0.96 for PC14HM xenografts; r = −0.04, p = 0.9 for PC14 xenografts and r = −0.015; p = 0.94 for total set of data). (c) Significant correlation was found between [Pi] and tumor volume (r = 0.66, p = 0.02 for PC14HM xenografts; r = 0.9, p = 3 × 10−5 for PC14 xenografts and r = 0.73, p = 5 × 10−5 for total set of data). Note significantly higher [Pi] values for PC14HM xenografts compared to PC14 xenografts (mean [Pi] = 2.2 ± 0.2 mM and [Pi] = 1.6 ± 0.2 mM, correspondingly; p = 0.047). Black and red lines represent linear fits for PC14 and PC14HM data sets, respectively.