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. 2017 Jan 24;7:41254. doi: 10.1038/srep41254

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The results from proteomics revealed that (A) there are 14 common up-regulated proteins, (B) 20 common down-regulated proteins, and (C) 43 common differentially expressed proteins at the VOSL, CD, Dehy, and Cos-treated groups. Moreover, (D) the heatmap and cluster analysis revealed that the VOLS-treated group shared the most differentially expressed proteins with the CD-treated group, which further demonstrated that CD is the most important anti-breast cancer ingredients in VOSL and share the same pharmacological mechanisms with VOSL.