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. 2017 Jan 24;7:41220. doi: 10.1038/srep41220

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Pearson correlations between liver enzymes that metabolize cyclophosphamide: Cyp2b10, Cyp3a13 and splenic (a,b) and hypothalamic (d,e) inflammatory mediators. Cbr1, responsible for doxorubicin metabolism and its relation to splenic (c) and hypothalamic (f) inflammatory gene transcription after chemotherapy at ZT 2 or ZT 14. (*p < 0.05, **p < 0.01).