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. 2016 Nov 28;12(1):183–190. doi: 10.1021/acschembio.6b00898

Figure 6.

Figure 6

Immune response profiles elicited by LAM extracted from conditional aftB mutant cultured in the presence and absence of acetamide. (a) TLR4-dependent NF-κB activity by human HEK293-TLR4 cell line in response to the lipoglycans. (b) TLR2-dependent NF-κB activity by human HEK293-TLR2 cell line in response to the lipoglycans. TLR2-dependent NF-κB (c) activation and IL-8 (d) production by human monocyte/macrophage THP1 cell line in response to lipoglycans. TLR2-dependent NF-κB (e) activation and IL-8 (f) production by human THP-1 cells in response to lipoglycans were tested using blocking antibody anti-TLR-2. Results are mean ± SD from n = 2 (a–c, e) or n = 3 (d, f) and are from one representative of two (d, f) or three (a–c, e) independent experiments. The ×10 means that the concentration of cytokine detected is amplified 10-fold. *< 0.05; n.i., not induced.