Table 2. LS mean change of clinical endpoints after the intervention in the ITT population.
| Variable | Treatment (N = 110) | Placebo (N = 111) | Treatment effect | P-value |
|---|---|---|---|---|
| Mean change (95% CI) | Mean change (95% CI) | Mean difference (95% CI) | ||
| LDL-C (mmol/L) | −0.154 (−0.233, −0.076) | 0.111 (0.034, 0.188) | −0.265 (−0.375, −0.155) | <0.0001 |
| HDL-C (mmol/L) | −0.055 (−0.082, −0.027) | −0.072 (−0.099, −0.045) | 0.017 (−0.022, 0.055) | 0.395 |
| Total cholesterol (mmol/L) | −0.236 (−0.32, −0.151) | 0.026 (−0.057, 0.109) | −0.262 (−0.38, −0.143) | <0.0001 |
| Triglycerides (mmol/L) | 0.066 (−0.022, 0.155) | 0.093 (0.006, 0.179) | −0.026 (−0.15, 0.097) | 0.674 |
| Creatinine (μmol/L) | 1.229 (0.438, 2.021) | 1.906 (1.13, 2.683) | −0.677 (−1.786, 0.433) | 0.231 |
| Fasting glucose (mmol/L) | 0.019 (−0.048, 0.085) | −0.023 (−0.088, 0.042) | 0.042 (−0.051, 0.135) | 0.379 |
| Systolic blood pressure (mmHg) | −2.749 (−4.4, −1.097) | −1.438 (−3.052, 0.176) | −1.311 (−3.62, 0.999) | 0.265 |
| Diastolic blood pressure (mmHg) | 0.177 (−0.875, 1.229) | 2.11 (1.083, 3.138) | −1.934 (−3.405, −0.462) | 0.01 |
| Body temperature (°C) | −0.037 (−0.075, 0.001) | −0.018 (−0.054, 0.019) | −0.019 (−0.072, 0.033) | 0.469 |
| Weight (kg) | 0.311 (0.009, 0.613) | 0.028 (−0.268, 0.323) | 0.284 (−0.139, 0.706) | 0.187 |
| Height (cm) | −0.5 (−0.708, −0.292) | −0.405 (−0.609, −0.202) | −0.095 (−0.386, 0.196) | 0.522 |
| BMI (kg/m2) | 0.262 (0.129, 0.395) | 0.13 (0, 0.26) | 0.132 (−0.054, 0.317) | 0.165 |
| Waist circumference (cm) | −0.699 (−1.040, −0.359) | −0.669 (−0.998, −0.340) | −0.031 (−0.504, 0.443) | 0.899 |
| Hip circumference (cm) | −0.235 (−0.733, 0.264) | −0.43 (−0.907, 0.047) | 0.195 (−0.495, 0.885) | 0.577 |
Baseline value was adjusted in the model.