Table 5. Univariate analysis of factors in patients with interim PET/CT (n = 34).
| Risk Factor | PFS |
OS |
||||
|---|---|---|---|---|---|---|
| Mean (SE) | 95% CI | P | Mean (SE) | 95% CI | P | |
| Sex | ||||||
| Male | 16.98 (2.50) | 12.09–21.88 | 0.260 | 28.11 (2.66) | 22.91–33.32 | 0.670 |
| Female | 40.37 (6.16) | 28.30–52.45 | 43.83 (5.55) | 32.96–54.71 | ||
| Age | ||||||
| ≤60 | 34.81 (4.49) | 26.00–43.61 | 0.715 | 41.36 (4.02) | 33.49–49.24 | 0.721 |
| >60 | 16.50 (5.76) | 5.21–27.79 | 31.00 (4.33) | 22.51–39.49 | ||
| B symptoms | ||||||
| No | 43.92 (5.62) | 32.90–54.94 | 0.072 | 48.53 (4.14) | 40.46–56.70 | 0.112 |
| Yes | 21.74 (3.96) | 13.98–29.49 | 29.21 (3.49) | 22.38–36.04 | ||
| ECOG | ||||||
| <2 | 20.95 (2.36) | 16.32–25.58 | 0.684 | 25.54 (1.75) | 22.11–28.97 | 0.954 |
| ≥2 | 30.67 (9.97) | 11.13–50.21 | 41.33 (7.98) | 25.70–56.97 | ||
| LDH level | ||||||
| ≤245 U/L | 31.56 (3.63) | 24.45–38.67 | 0.051 | 34.50 (2.86) | 28.90–40.10 | 0.402 |
| >245 U/L | 24.75 (6.27) | 12.46–37.04 | 37.71 (5.99) | 25.96–49.46 | ||
| IPI score | ||||||
| 0–1 | 21.58 (2.37) | 16.94–26.22 | 0.332 | 25.44 (1.75) | 22.01–28.88 | 0.900 |
| 2–5 | 26.86 (9.24) | 8.74–44.98 | 42.29 (7.68) | 27.24–57.34 | ||
| KPI score | ||||||
| 0–2 | 41.36 (4.74) | 32.07–50.66 | 0.019 | 48.22 (3.57) | 41.22–55.23 | 0.032 |
| 3–4 | 17.75 (4.81) | 8.32–27.18 | 25.38 (4.39) | 16.77–33.98 | ||
| Ann Arbor Stage | ||||||
| I/II | 20.28 (2.21) | 15.94–24.61 | 0.268 | 32.26 (1.97) | 28.40–36.12 | 0.023 |
| III/IV | 28.36 (7.38) | 13.89–42.83 | 31.07 (6.60) | 18.14–44.01 | ||
| I–PET | ||||||
| Negative | 44.36 (4.70) | 35.14–53.57 | 0.004 | 49.84 (3.42) | 43.13–56.55 | 0.015 |
| Positive | 14.00 (3.16) | 7.81–20.19 | 23.09 (3.29) | 16.63–29.54 | ||
| I–PET3 | ||||||
| Negative (n = 13) | 24.65 (2.17) | 20.39–28.90 | 0.047 | — | — | 0.058 |
| Positive (n = 9) | 15.78 (3.71) | 8.51–23.05 | — | — | ||
| I-PET4 | ||||||
| Negative (n = 6) | 39.50 (9.01) | 21.84–57.16 | 0.086 | 40.83 (8.20) | 24.76–56.91 | 0.214 |
| Positive (n = 5) | 10.60 (4.69) | 1.41–19.79 | 17.60 (3.34) | 11.05–24.15 | ||
ECOG, Eastern Cooperative Oncology Group; IPI, International Prognostic Index; KPI, Korean prognostic index; I-PET3, interim PET/CT carried out after 3 cycles of chemotherapy; I-PET4, interim PET/CT carried out after 4 cycles of chemotherapy; PFS, progression-free survival; OS, overall survival.