Table 1.
Assessing macroscopic hepatic lesions in CD1 mice
Group | Treatment | Lesion score (mean ± SEM) | Reduction (%) |
---|---|---|---|
1 | Untreated uninfected | ||
2 | Infected | 12.0 ± 1.5 | |
3 | Adjuvant treated | 9.3 ± 1.8 | 22 |
4 | B6 + T14 | 8.3 ± 1.8 | 31 |
5 | B1 + B5 + B6 | 10.3 ± 1.6 | 14 |
6 | T14 + T15 + T16 | 6.6 ± 0.6 | 45* |
7 | B1 + B2 + B5 + B6 + T14 + T15 + T16 | 7.3 ± 1.3 | 39* |
The mice were immunised with combinations of synthetic peptides containing B- and T-cell epitopes using the ADAD vaccination system which had been orally challenged with 7 F. hepatica metacercariae
*p < 0.05 compared to infected controls