Table 2.
Genes having the highest differential expression associated with immune response-related pathways
| Gene symbol | Description | p-value | Fold change | Associated pathway |
|---|---|---|---|---|
| S100A8 | S100 calcium binding protein A8 | 1.62E-03 | 5.934 | IL12 signalling and production in macrophages |
| Production of nitric oxide and reactive oxygen species | ||||
| MMP9 | Matrix metallopeptidase 9 | 3.07E-03 | 4.501 | IL8 signalling |
| Leukocyte extravasation signalling | ||||
| CXCR2 | Chemokine (C-X-C motif) receptor 2 | 3.39E-04 | 3.401 | IL8 signalling |
| IFITM1 | Interferon induced transmembrane protein 1 | 2.13E-03 | 2.375 | IFN signalling |
| CCR3 | Chemokine (C-C motif) receptor 3 Gene | 1.31E-03 | 1.655 | CCR3 signalling in eosinophils |
| Chemokine signalling | ||||
| ACTA2 | Actin, alpha 2, smooth muscle, aorta | 1.77E-03 | 1.640 | Crosstalk between DC and NK cells |
| Leukocyte extravasation signalling | ||||
| Integrin signalling | ||||
| TAB1 | Mitogen-activated protein kinase 7 interacting protein 1 | 2.82E-03 | 1.276 | iNOS signalling |
| NF-kB signalling | ||||
| IL10 signalling | ||||
| Toll-like receptor signalling | ||||
| CD40LG | CD40 ligand | 1.41E-03 | −1.740 | T helper cell differentiation |
| CD40 signalling | ||||
| IL12 signalling and production in macrophages | ||||
| NF-kB signalling | ||||
| JUN | Jun oncogene | 4.08E-03 | −1.587 | CD28 signalling in T helper cells |
| IL12 signalling and production in macrophages | ||||
| Production of nitric oxide and reactive oxygen species | ||||
| T-cell receptor signalling | ||||
| iNOS signalling | ||||
| IL8 signalling | ||||
| IL10 signalling | ||||
| PLCG1 | phospholipase C, gamma 1 | 5.33E-03 | −1.541 | iCOS-iCOSL signalling in T-helper cells |
| PCK signalling in T-lymphocytes | ||||
| Production of nitric oxide and reactive oxygen species | ||||
| Phospholipase C signalling | ||||
| IL15 signalling | ||||
| PRKCQ | protein kinase C, theta | 3.14E-03 | −1.461 | T-cell receptor signalling |
| CCR5 signalling in macrophages | ||||
| Natural killer cells signalling | ||||
| Apoptosis signalling | ||||
| B-cell receptor signalling | ||||
| PRKD3 | protein kinase D3 | 6.26E-03 | −1.440 | Calcium-induced T-lymphocyte apoptosis |
| LPS stimulated MAPK signalling | ||||
| CCR5 signalling in macrophages | ||||
| CCR3 signalling in eosinophils | ||||
| CXCR4 signalling |
The genes analysed here were used when comparing non-immunised mice to mice immunised with a combination of T-cell-epitope-containing peptides (T14 + T15 + T16)