Fig. 1.

The illustrative diagram of the two-pass random walk with restart on drug-disease heterogenous network. For a candidate association between drug c _i and disease d _j, a two-pass random walk process is run to compute its final confidence score. The nodes covered in the initial probability distribution are in gold color, and the candidate drug-disease association is represented by dashed line. a The drug-centric random walk process starts from drug c _i and all its known associated diseases. b The disease-centric random walk process starts from disease d _j and all known associated drugs