Table 3.
Top 20 targets predicted for Aripiprazole and Theophylline
| Aripiprazole | Theophylline | ||
|---|---|---|---|
| Rank | Target | Rank | Target |
| 1 | 5-hydroxytryptamine receptor 2A | 1 | cAMP-specific 3’,5’-cyclic phosphodiesterase 4A |
| 2 | Alpha-1B adrenergic receptor | 2 | Histone deacetylase 2 |
| 3 | Muscarinic acetylcholine receptor M2 | 3 | Adenosine receptor A2a |
| 4 | 5-hydroxytryptamine receptor 2C | 4 | Adenosine receptor A1 |
| 5 | D(1) dopamine receptor | 5 | cGMP-inhibited 3’,5’-cyclic phosphodiesterase A |
| 6 | Alpha-2C adrenergic receptor | 6 | cAMP-specific 3’,5’-cyclic phosphodiesterase 4B |
| 7 | Histamine H1 receptor | 7 | Adenosine receptor A2b |
| 8 | Muscarinic acetylcholine receptor M3 | 8 | cGMP-specific 3’,5’-cyclic phosphodiesterase |
| 9 | D(2) dopamine receptor | 9 | Adenosine receptor A3 |
| 10 | Muscarinic acetylcholine receptor M1 | 10 | Thymidylate synthase |
| 11 | 5-hydroxytryptamine receptor 1B | 11 | Histone deacetylase 1 |
| 12 | Delta-type opioid receptor | 12 | Cyclin-dependent kinase 2 |
| 13 | D(4) dopamine receptor | 13 | Reverse transcriptase/RNaseH |
| 14 | D(3) dopamine receptor | 14 | Cap-specific mRNA (nucleoside-2’-O-)-methyltransferase |
| 15 | 5-hydroxytryptamine receptor 1D | 15 | Multi-sensor signal transduction histidine kinase |
| 16 | Alpha-1 adrenergic receptor | 16 | Alpha-1 adrenergic receptor |
| 17 | Muscarinic acetylcholine receptor M5 | 17 | Serine/threonine-protein kinase pim-1 |
| 18 | Muscarinic acetylcholine receptor M4 | 18 | Serine-protein kinase ATM |
| 19 | Alpha-2B adrenergic receptor | 19 | Proto-oncogene tyrosine-protein kinase Src |
| 20 | 5-hydroxytryptamine receptor 1A | 20 | Phosphatidylinositol 4,5-bisphosphate 3-kinase |
| catalytic subunit alpha isoform | |||
Targets in bold are the true known targets of the drugs