Fig. 1.

Baseline CT in patients with metastatic clear cell renal cell carcinoma and intermediate IMDC score (Left: prior to treatment, Right: following the treatment). a 72-year-old man: OS and PFS in this patient was 1074 and 1063 days, respectively with a baseline nSD = 0.66. Although the tumor remains heterogeneous in appearance there is response by RECIST criteria. b 40-year-old man: OS and PFS in this patient were poor at 159 and 113 days, respectively with a lower baseline nSD of 0.54. The tumor is slightly larger but stable by RECIST criteria. The list of significant parameters for 2 cases is shown in Table 6 below. As it can be seen from the table, higher nSD prior to and following treatment and higher percent change in lesion size (i.e., higher size reduction) were associated with higher survival; and higher entropy following treatment and entropy change predicted decreased survival. It should be noted that for PFS, only nSD prior to and following treatment were statistically significant parameters