Table 2.
Imaging parameters as predictors of OS
| Variable | P-value | Hazard ratio | 95% CI |
|---|---|---|---|
| Mean positive pixel intensity prior to treatment | 0.34 | 1.01 | 0.98 – 1.05 |
| Mean positive pixel intensity following treatment | 0.77 | 1.00 | 0.99 – 1.02 |
| SD prior to treatment | 0.24 | 0.98 | 0.96 – 1.01 |
| SD following treatment | 0.46 | 0.99 | 0.98 – 1.01 |
| Entropy prior to treatment | 0.27 | 1.74 | 0.65 – 4.68 |
| Entropy following treatment | 0.02 | 2.68 | 1.14 – 6.29 |
| nSD prior to treatment | 0.01 | 0.01 | 0.00 – 0.29 |
| nSD following treatment | 0.01 | 0.02 | 0.001 – 0.39 |
| Kurtosis prior to treatment | 0.26 | 1.24 | 0.85 – 1.82 |
| Kurtosis following treatment | 0.78 | 1.03 | 0.81 – 1.32 |
| Skewness prior to treatment | 0.15 | 2.02 | 0.77 – 5.30 |
| Skewness following treatment | 0.30 | 1.47 | 0.70 – 3.09 |
| Percent change in size | 0.02 | 0.97 | 0.94 – 0.99 |
| Mean pixel intensity Change | 0.37 | 0.99 | 0.98 – 1.01 |
| SD Change | 0.80 | 1.14 | 0.42 – 3.09 |
| Entropy Change | 0.04 | 87.77 | 1.26 – 6115.69 |
| nSD Change | 0.39 | 0.18 | 0.004 – 8.56 |
| Kurtosis Change | 0.46 | 0.66 | 0.21 – 2.02 |
| Skewness Change | 0.98 | 0.99 | 0.60 – 1.65 |
Entries in bold were significant
Abbreviations: SD standard deviation, nSD size normalized standard deviation OS overall survival