Table 1.

Inclusion and exclusion criteria

Inclusion criteria:
Signed informed consent form
Age ≥18 years
Patients with chronic heart failure, as defined by the European Society of Cardiology (update 2016)
New York Heart Association (NYHA) functional class II–IV
Patients who require diuretic therapy for maintain euvolaemia
Stable clinical condition during index hospitalization with established proper diuretic dosage
Exclusion criteria:
Acute coronary syndrome
Hypertrophic cardiomyopathy
Uncontrolled hypertension
Uncontrolled diabetes
Serum potassium >6.0 mmol/l
Serum creatinine >2.5 mg/dl
Malignancy
Life expectancy <1 year
Planned valve surgery or heart transplantation