Skip to main content
Journal of Virology logoLink to Journal of Virology
. 1978 Mar;25(3):944–947. doi: 10.1128/jvi.25.3.944-947.1978

Antiviral Action of a Rifamycin Derivative: Formation of Rous Sarcoma Virus Particles Deficient in 60 to 70S RNA

Charles Szabo 1, Mina J Bissell 1
PMCID: PMC525993  PMID: 205684

Abstract

Growth of Rous sarcoma virus-transformed cells in the presence of rifazone-82, a rifamycin derivative, results in the formation of noninfectious virus particles lacking 60 to 70S RNA.

Full text

PDF
944

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ben-Ishai Z., Heller E., Goldblum N., Becker Y. Rifampicin and poxvirus replication. Nature. 1969 Oct 4;224(5214):29–32. doi: 10.1038/224029a0. [DOI] [PubMed] [Google Scholar]
  2. Bissell M. J., Hatie C., Tischler A. N., Calvin M. Preferential inhibition of the growth of virus-transformed cells in culture by rifazone-82, a new rifamycin derivative. Proc Natl Acad Sci U S A. 1974 Jun;71(6):2520–2524. doi: 10.1073/pnas.71.6.2520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Calvin M., Joss U. R., Hackett A. J., Owens R. B. Effect of rifampicin and two of its derivatives on cells infected with Moloney sarcoma virus. Proc Natl Acad Sci U S A. 1971 Jul;68(7):1441–1443. doi: 10.1073/pnas.68.7.1441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Canaani E., Helm K. V., Duesberg P. Evidence for 30-40S RNA as precursor of the 60-70S RNA of Rous sarcoma virus. Proc Natl Acad Sci U S A. 1973 Feb;70(2):401–405. doi: 10.1073/pnas.70.2.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Duesberg P., Helm K. V., Canaani E. Properties of a soluble DNA polymerase isolated from Rous sarcoma virus. Proc Natl Acad Sci U S A. 1971 Apr;68(4):747–751. doi: 10.1073/pnas.68.4.747. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hartmann G., Honikel K. O., Knüsel F., Nüesch J. The specific inhibition of the DNA-directed RNA synthesis by rifamycin. Biochim Biophys Acta. 1967;145(3):843–844. doi: 10.1016/0005-2787(67)90147-5. [DOI] [PubMed] [Google Scholar]
  7. Hunter E., Hayman M. J., Rongey R. W., Vogt P. K. An avian sarcoma virus mutant that is temperature sensitive for virion assembly. Virology. 1976 Jan;69(1):35–49. doi: 10.1016/0042-6822(76)90192-6. [DOI] [PubMed] [Google Scholar]
  8. Moreau M. C., Sanzey B. Rifampin-susceptible mutant of vesicular stomatitis virus: protein and RNA synthesis. J Virol. 1977 Jan;21(1):41–53. doi: 10.1128/jvi.21.1.41-53.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Moss B., Rosenblum E. N., Katz E., Grimley P. M. Rifampicin: a specific inhibitor of vaccinia virus assembly. Nature. 1969 Dec 27;224(5226):1280–1284. doi: 10.1038/2241280a0. [DOI] [PubMed] [Google Scholar]
  10. Stoltzfus C. M., Snyder P. N. Structure of B77 sarcoma virus RNA: stabilization of RNA after packaging. J Virol. 1975 Nov;16(5):1161–1170. doi: 10.1128/jvi.16.5.1161-1170.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Subak-Sharpe J. H., Timbury M. C., Williams J. F. Rifampicin inhibits the growth of some mammalian viruses. Nature. 1969 Apr 26;222(5191):341–345. doi: 10.1038/222341a0. [DOI] [PubMed] [Google Scholar]
  12. Szabo C., Bissell M. J., Calvin M. Inhibition of infectious Rous sarcoma virus production by rifamycin derivative. J Virol. 1976 May;18(2):445–453. doi: 10.1128/jvi.18.2.445-453.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Thompson F. M., Tischler A. N., Adams J., Calvin M. Inhibition of three nucleotide polymerases by rifamycin derivatives. Proc Natl Acad Sci U S A. 1974 Jan;71(1):107–109. doi: 10.1073/pnas.71.1.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ting R. C., Yang S. S., Gallo R. C. Reverse transcriptase, RNA tumour virus transformation and derivatives of rifamycin SV. Nat New Biol. 1972 Apr 12;236(67):163–166. doi: 10.1038/newbio236163a0. [DOI] [PubMed] [Google Scholar]
  15. Tischler A. N., Joss U. R., Thompson F. M., Calvin M. Synthesis of some rifamycin derivatives as inhibitors of an RNA-instructed DNA polymerase function. J Med Chem. 1973 Oct;16(10):1071–1075. doi: 10.1021/jm00268a001. [DOI] [PubMed] [Google Scholar]
  16. Wehrli W., Staehelin M. Actions of the rifamycins. Bacteriol Rev. 1971 Sep;35(3):290–309. doi: 10.1128/br.35.3.290-309.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES