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. 2017 Jan 24;14:4. doi: 10.1186/s12977-017-0328-7

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — HIV signaling through CD4 and CCR5 alters the landscape of GTPase-regulating proteins. a Rho family GTPases are regulated by guanine dissociation inhibitors (GDIs), guanosine exchange factors (GEFs), and GTPase activating proteins (GAPs). GTPase-regulating proteins with ±0.5 log₂ fold changes in phosphopeptide expression levels following HIV-1 signaling via CD4 and CCR5 as compared to a microvesicle control are listed. b Log₂ fold changes in intensity of phoshopeptides from GTPase-regulating proteins 1 min after exposing cells to inactivated HIV-1 viruses