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. 2017 Jan 23;9:4. doi: 10.1186/s13073-016-0393-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Examples of mutational 3D clusters in tumor suppressor genes. a Residues in 3D clusters in PTEN highlighted in the protein sequence (top) and a protein structure (bottom). The 3D cluster residues surround the catalytic site. b Residues in 3D clusters in CDH1 (E-cadherin) highlighted in the protein sequence (top) and a protein structure (bottom). The 3D cluster mutations are likely to disrupt the critical calcium-binding site (calcium atoms in red). c 3D clusters in KEAP1 in the protein sequence (top) and a protein structure (bottom). Most of the 3D cluster mutations are in the NRF2-binding region (NRF2 peptide in purple)