Table 1.
POLA2 and its interactants based on published experimental evidence
| GENE SYMBOL | GENE NAME | CHROMOSOMAL LOCATION | EXON COUNT | GENE ONTOLOGY (ACCESSION) | EXPERIMENTAL SOURCE | ||
|---|---|---|---|---|---|---|---|
| Gene of interest | |||||||
| POLA2 | Polymerase (DNA) alpha 2, accessory subunit | 11q13.1 | 21 | GO:0003887 | GO:0006260 | - | |
| Interactants | |||||||
| AKTIP | AKT interacting protein | 16q12.2 | 11 | GO:0001934 | GO:0005515 | Two-hybrid | |
| APP | Amyloid beta precursor protein | 21q21.3 | 20 | GO:0045931 | GO:0051425 | Reconstituted Complex | |
| ASCC2 | Activating signal cointegrator 1 complex subunit 2 | 22q12.1 | 23 | GO:0006355 | Two-hybrid | ||
| ATP5C1 | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 | 10p15.1 | 10 | GO:0006754 | GO:0016887 | Two-hybrid | |
| CAPN1 | Calpain 1 | 11q13 | 24 | GO:0005515 | GO:0008284 | Affinity Capture-MS | |
| CIAO1 | Cytosolic iron-sulfur assembly component 1 | 2q11.2 | 7 | GO:0005515 | GO:0008284 | Affinity Capture-MS | |
| CPE | Carboxypeptidase E | 4q32.3 | 9 | GO:0050839 | GO:0072657 | Two-hybrid | |
| CRELD1 | Cysteine rich with EGF like domains 1 | 3p25.3 | 12 | GO:0005509 | Two-hybrid | ||
| DCP2 | Decapping mRNA 2 | 5q22.2 | 11 | GO:0005515 | GO:0006402 | Two-hybrid | |
| DDX24 | DEAD-box helicase 24 | 14q32 | 9 | GO:0044822 | Two-hybrid | ||
| DHX34 | DEAH-box helicase 34 | 19q13.3 | 21 | GO:0044822 | Two-hybrid | ||
| EIF6 | Eukaryotic translation initiation factor 6 | 20q12 | 8 | GO:0005515 | Two-hybrid | ||
| EPB41L1 | Erythrocyte membrane protein band 4.1 like 1 | 20q11.2-q12 | 37 | GO:0005515 | Co-fractionation | ||
| EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit | 7q35-q36 | 25 | GO:0005515 | GO:0031490 | GO:0042127 | Two-hybrid |
| FGFR3 | Fibroblast growth factor receptor 3 | 4p16.3 | 19 | GO:0005515 | GO:0008543 | GO:0042127 | Two-hybrid |
| FRZB | Frizzled-related protein | 2q32.1 | 6 | GO:0017147 | GO:0043065 | Two-hybrid | |
| HDAC6 | Histone deacetylase 6 | Xp11.23 | 32 | GO:0005515 | GO:0016575 | GO:0045892 | Two-hybrid |
| HELB | Helicase (DNA) B | 12q14.3; 12q | 14 | GO:0006260 | GO:0044822 | Reconstituted Complex | |
| HEXIM1 | Hexamethylene bis-acetamide inducible 1 | 17q21.31 | 1 | GO:0005515 | GO:0045892 | Co-fractionation | |
| IGFBP3 | Insulin like growth factor binding protein 3 | 7p12.3 | 5 | GO:0005515 | GO:0043065 | Two-hybrid | |
| KCNE3 | Potassium voltage-gated channel subfamily E regulatory subunit 3 | 11q13.4 | 3 | GO:0005515 | GO:0015459 | Two-hybrid | |
| KLF6 | Kruppel-like factor 6 | 10p15 | 4 | GO:0005515 | GO:0045893 | Two-hybrid | |
| LRPAP1 | LDL receptor related protein associated protein 1 | 4p16.3 | 9 | GO:0070326 | Two-hybrid | ||
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 4q27 | 5 | GO:0005515 | GO:0007093 | Affinity Capture-MS | |
| MMS19 | MMS19 homolog, cytosolic iron-sulfur assembly component | 10q24-q25 | 32 | GO:0005515 | GO:0045893 | Affinity Capture-MS | |
| NR4A1 | Nuclear receptor subfamily 4 group A member 1 | 12q13 | 13 | GO:0003677 | GO:0005515 | GO:0045786 | Two-hybrid |
| PARP1 | Poly(ADP-ribose) polymerase 1 | 1q41-q42 | 23 | GO:0003677 | GO:0005515 | GO:0006281 | Affinity Capture-Western; Far Western |
| POLA1 | Polymerase (DNA) alpha 1, catalytic subunit | Xp22.1-p21.3 | 38 | GO:0003887 | GO:0006260 | Co-fractionation; Reconstituted Complex | |
| POLD2 | Polymerase (DNA) delta 2, accessory subunit | 7p13 | 13 | GO:0003887 | GO:0006260 | Co-fractionation | |
| POP7 | POP7 homolog, ribonuclease P/MRP subunit | 7q22 | 2 | GO:0005515 | GO:0044822 | Co-fractionation | |
| PRIM1 | Primase (DNA) subunit 1 | 12q13 | 13 | GO:0006270 | Co-fractionation | ||
| PRIM2 | Primase (DNA) subunit 2 | 6p12-p11.1 | 19 | GO:0006270 | Co-fractionation | ||
| PRPF38A | Pre-mRNA processing factor 38A | 1p32.3 | 10 | GO:0005515 | GO:0044822 | Two-hybrid | |
| RAE1 | Ribonucleic acid export 1 | 20q13.31 | 15 | GO:0003723 | Affinity Capture-MS | ||
| RBM23 | RNA binding motif protein 23 | 14q11.2 | 19 | GO:0003723 | GO:0005515 | Two-hybrid | |
| REPIN1 | Replication initiator 1 | 7q36.1 | 6 | GO:0003677 | GO:0006260 | GO:0044822 | Co-fractionation |
| SCYL1 | SCY1 like pseudokinase 1 | 11q13 | 18 | GO:0006355 | GO:0006890 | Co-fractionation | |
| SETDB1 | SET domain bifurcated 1 | 1q21 | 22 | GO:0005515 | GO:1990841 | Two-hybrid | |
| SNU13 | SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) | 22q13 | 5 | GO:0005515 | GO:0044822 | GO:0051117 | Two-hybrid |
| STK40 | Serine/threonine kinase 40 | 1p34.3 | 12 | GO:0010468 | GO:0043066 | GO:0043408 | Two-hybrid |
| UBE2O | Ubiquitin conjugating enzyme E2 O | 17q25.1 | 19 | GO:0005515 | GO:0006513 | GO:0044822 | Co-fractionation |
| ULK2 | Unc-51 like autophagy activating kinase 2 | 17p11.2 | 29 | GO:0005515 | GO:0010506 | Two-hybrid | |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 10q25.3 | 23 | GO:0042803 | Two-hybrid | ||
| XPO1 | Exportin 1 | 2p15 | 29 | GO:0003723 | GO:0005515 | GO:0006611 | Affinity Capture-MS |
Gene symbol, gene name, chromosomal location, number of exons and Gene Ontology accession numbers of each gene are shown. A total of 44 interactants were found for POLA2, as inferred from physical interactions, sequence or structural similarities as well as direct experimental assays. Brief description of the experimental source is given. Data were compiled from the National Center for Biotechnology Information (NCBI) and Gene Ontology (GO) framework databases