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Effect of intracolonic TNBS administration (A–D) or DSS treatment (E and F) on survival rate (A), weight (B), macroscopic-damage score (C and E), and MPO activity (D and F) in PAR1-deficient mice (PAR1–/–) and WT littermates (PAR1+/+). Values are mean ± SEM; minimum of n = 10 per group. *Significantly different from PAR1–/– in B, and significantly different from WT in C–F, P < 0.05.
