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Macroscopic-damage score (A) and MPO activity (B) induced by the intracolonic administration of the PAR1-activating peptide TFLLR-NH2 (200 μg/mouse) in PAR1-deficient mice (PAR1–/–) and their WT littermates (PAR1+/+), compared with naive mice (time 0). Values are mean ± SEM; n = 8 per group. *Significantly different from naive mice (time 0) of the corresponding genotype, P < 0.05.
