Figure 7.
Effect of systemic (Syst.) treatment with a PAR1 antagonist on survival rate (A), MPO activity (B and F), body weight (C and G), macroscopic- and microscopic-damage score (D, E, and H), and disease activity (I) in BALB/c mice, 7 days after the induction of colitis by intracolonic administration of TNBS at the dose of 2 mg per mouse in 50% ethanol (A and B) or at the dose of 1 mg/kg in 50% ethanol (C–F), or 8 days after the induction of DSS colitis (G–I). Values are mean ± SEM; n = 12 per group. *Significantly different from naive group; **significantly different from vehicle-treated group.