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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Expert Rev Cardiovasc Ther. 2016 Jul 15;14(10):1119–1131. doi: 10.1080/14779072.2016.1210510

Figure 1. Genetic approaches to defining the genetic architecture of atrial fibrillation (AF).

Figure 1

Linkage analysis, next generation sequencing (NGS) and candidate gene approaches have identified rare genetic variants in single genes in large familial kindreds with early-onset AF. Conversely, genetic association studies, i.e., genome-wide association studies have uncovered common genetic variants associated with AF in many genes. (Filled in symbols indicate individuals with AF and unfilled symbols represent controls).