Figure 3.
Comparing skill-based and aerobic exercise in a rodent model of dopamine depletion implicates Cognitive Circuits.
Rats lesioned with 6-OHDA were exercised on a skilled wheel where selective rungs were removed or an aerobic wheel with a smooth insert. During exercise rats were exposed to the radiotracer [14C]-iodoantipyrine, brains were removed, subjected to autoradiography and mapping/functional connectivity analysis. Results show elevated rCBF in the PFC and motor cortex with skill-based exercise compared to aerobic exercise. Images from Wang and Holschneider.