Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cortical distal tubular cell. Activation of NaCl cotransporter (NCC) in pseudohypoaldosteronism type II (Gordon syndrome) causes hyperchloremic hyperkalemic acidosis. Inhibition of NCC by thiazide, or an inactivating mutation in Gitelman's syndrome are causes of hypochloremic hypokalemic alkalosis. A decrease in NCC is in mechanism for the “aldosterone escape” in primary hyperaldosteronism.
