Table 2.
Characteristics of patients presenting to the Emergency Department with Drug-Induced Anaphylaxis
| Variable (%, 95% CI) | Montreal Children’s Hospital | Hôpital Sacré-Coeur |
|---|---|---|
| N | 29 | 52 |
| AAR (median, IQR) | 9.67 (4.6, 15.6) | 49.1 (38.0, 62.9) |
| Sex (% males) | 37.9 (19.1, 56.7) | 25.0 (12.8, 37.2) |
| Cases per year | ||
| 2012–2013 | 27.6 (10.3, 44.9) | 28.8 (16.1, 41.6) |
| 2013–2014 | 31.0 (13.1, 48.9) | 32.7 (19.5, 45.9) |
| 2014–2015 | 41.4 (22.3, 60.4) | 38.5 (24.8, 52.1) |
| Medication type | ||
| Antibiotics | 34.5 (16.1, 52.9) | 59.6 (45.8, 73.4) |
| Non-antibiotic drugs | 65.5 (47.1, 83.9) | 40.4 (26.6, 54.2) |
| Known drug allergy | 6.9 (0, 16.7) | 30.6 (17.2, 44.0) |
| Known food allergy | 20.7 (5.0, 36.4) | 12.2 (2.7, 21.8) |
| Known asthma | 24.1 (7.6, 40.7) | 4.1 (0, 9.8) |
| Reaction type | ||
| Milda | 13.8 (0.4, 27.1) | 0 |
| Moderateb | 79.3 (63.6, 95.0) | 82.7 (72.0, 93.3) |
| Severec | 6.9 (0, 16.7) | 17.3 (6.7, 27.9) |
| Treatment in ED | ||
| Epinephrine | 58.6 (39.6, 77.7) | 48.1 (34.0, 62.1) |
| Antihistamines | 41.4 (22.3, 60.4) | 78.8 (67.4, 90.3) |
| Steroids | 17.2 (2.6, 31.9) | 86.5 (76.9, 96.1) |
aSymptoms include urticaria, erythema, angioedema, oral pruritus, nausea, nasal congestion, sneezing, rhinorrhea or throat tightness
bSymptoms include crampy abdominal pain, diarrhea, recurrent vomiting, dyspnea, stridor, cough, wheeze, or “light-headedness”
cSymptoms include cyanosis, hypoxia, respiratory arrest, hypotension, dysrhythmia, confusion, or loss of consciousness