Fig. 1.

Flowchart for the analysis and exploration of disease methylation profiles and related pathways. The differentially methylated genes and differentially expressed genes were selected to construct the SDMN and HyDEN. The PsyGeNET also shares disease marker genes with the list of SDMGs and SCZCGs. By the analysis of cliques, functional complexes and enriched pathways, we (a) studied the methylation profiles with differential gene expression in schizophrenia, (b) discovered related pathways from enrichment analysis of schizophrenic differential methylation, and (c) identified shared disease mechanisms for schizophrenia and other major psychiatric disorders