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. 2016 Dec 5;9(Suppl 3):68. doi: 10.1186/s12920-016-0229-y

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — The ribosome-associated PPI network. The ribosome-associated PPI network constructed with SDMGs and SCZCGs revealed the regulatory role of epigenetic mechanism in schizophrenia. The red and green nodes are depicted as over- and under-expressed SCZCGs, respectively. The purple nodes are hypomethylated promoters. The ribosome biosynthesis is likely to be regulated by hypomethylated SDMGs which interacts with differentially expressed SCZCGs. The regulation of ribosome expression by the hypomethylated promoters may be crucial in the pathogenesis for schizophrenia