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. 2016 Oct 3;37(12):1563–1573. doi: 10.1038/aps.2016.97

Figure 1.

Figure 1

Hesperetin-mediated concentration-dependent blockage of Nav1.5 channels expressed in HEK 293 cells. (A) Original typical Nav1.5 currents recorded at −35 mV were elicited by application of 100-ms pulses causing depolarization from a holding potential of −120 mV to potentials ranging from −100 to +55 mV in the absence or presence of 10, 30, 100, or 300 μmol/L hesperetin. (B) The summarized data show the concentration-response curve for hesperetin-mediated Nav1.5 current inhibition. Nav1.5 currents were measured during 100-ms depolarizing pulses of −35 mV. The plots indicate the percentages of Nav1.5 current blockage induced by 3, 10, 30, 100, 300, or 600 μmol/L hesperetin. The normalized data were fitted with the Hill equation (n=7–8 for each concentration). Data are expressed as the mean±SEM. HSP indicates hesperetin.