Skip to main content
. 2016 Oct 3;37(12):1563–1573. doi: 10.1038/aps.2016.97

Figure 2.

Figure 2

Hesperetin-mediated voltage-dependent Nav1.5 current inhibition. (A) Voltage-dependent Nav1.5 currents evoked by 200-ms pulses causing depolarization (increasing in steps of 5 mV every 1 s) from a holding potential of −120 mV to potentials ranging from −100 to +55 mV were recorded in a representative cell. (B) The summarized data show the Nav1.5 current-voltage (I–V) relationships before and after the application of 30 or 100 μmol/L hesperetin and washout (n=9) (C) The current inhibition percentage induced by the application of 100 μmol/L hesperetin is plotted against the membrane potential. Data are expressed as the mean±SEM. *P<0.05, **P<0.01 vs control. HSP: hesperetin.