Table 2.
Ex Vivo Anthelmintic Activity of D. ornata Compounds 1–10 toward A. ceylanicuma
| % survival of A. ceylanicum relative to controlb at 25 µg/mL | ||||||
|---|---|---|---|---|---|---|
| compound | day 1 | day 2 | day 3 | day 4 | day 5 | corresponding µM concentrations |
| 1 | 100 | 97 (±3.3) | 90 (±0.0) | 83 (±5.7) | 83 (±5.7) | 7.3 |
| 2 | 100 | 100 | 100 | 100 | 100 | 8.6 |
| 3 | 100 | 93 (±3.3) | 83 (±5.7) | 80 (±5.7) | 73 (±3.3) | 8.2 |
| 4 | 100 | 100 | 100 | 100 | 93 (±6.7) | 6.1 |
| 5 | 100 | 100 | 90 (±5.7) | 80 (±5.7) | 80 (±5.8) | 7.3 |
| 6 | 100 | 97 (±3.3) | 93 (±3.3) | 93 (±3.3) | 87 (±3.3) | 7.0 |
| 7 | 100 | 100 | 100 | 97 (±3.3) | 90 (±5.8) | 6.1 |
| 8 | 100 | 100 | 100 | 100 | 100 | 5.8 |
| 9 | 100 | 50 (±5.8) | 40 (±0.0) | 0 | 0 | 6.3 |
| 10 | 77 (±5.8) | 3 (±3.3) | 0 | 0 | 0 | 6.0 |
a
Data in the table are in mean values ± standard error (SE).
b
Control wells contained medium and 1% DMSO and uniformly exhibited >95% survival at day 5.