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. Author manuscript; available in PMC: 2017 Nov 10.
Published in final edited form as: J Med Chem. 2016 Oct 26;59(21):9942–9959. doi: 10.1021/acs.jmedchem.6b01385

Table 3.

In vitro inhibition of recombinant HDACs 1, 2, and 3 and HEK293 Lysate for series 3 inhibitorsa

graphic file with name nihms840579t28.jpg
Name R Group IC50a (nM)
HDAC1 HDAC2 HDAC3 HEK293
3a graphic file with name nihms840579t29.jpg 29.49 ±
10.71		 76.57 ±
9.74		 19.71 ±
1.41		 171.1 ±
34.23
3b graphic file with name nihms840579t30.jpg 11.81 ±
4.16		 95.45 ±
34.15		 0.95 ±
0.19 		124.4 ±
14.02
3c graphic file with name nihms840579t31.jpg 60.17 ±
20.97		 70.03 ±
26.38		 3.67 ±
2.86 		494.3 ±
209.6
3d graphic file with name nihms840579t32.jpg 47.36 ±
16.79		 99.56 ±
17.44		 32.55 ±
1.15 		690.7 ±
54.67
3e graphic file with name nihms840579t33.jpg 81.36 ±
11.96		 139.2 ±
29.9		 149.8 ±
81.63		 1718 ±
139.1
a

IC50 values (bold) are the mean of at least three experiments ± the Standard Error of the Mean.