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. 2016 Nov 24;7(11):e2483. doi: 10.1038/cddis.2016.295

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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A2 deletion reduced IR injury-induced necroptotic cell death. (a) PI images and quantification (b) of PI-positive cells showing increases in necroptotic cells in the WT retina at 6 h after I/R injury. Results are presented as a fold change of WT sham. ***P<0.001 versus WT Sham, *P<0.05 versus WT I/R. WT sham and A2^−/− Sham: n=3, WT I/R: n=5, A2^−/− I/R: n=4. Scale bar 50 μM. IPL, inner plexiform layer; OPL, outer plexiform layer; ONL, outer nuclear layer. Data are presented as mean±S.E.M. (c) Western blot and quantitative analysis (d) showing increases in RIP-3 expression in WT retina at 6 h after I/R injury. The red arrow points to the band of interest. Other bands are nonspecific. Molecular size marker is shown on the left. Results are presented as a fold change of WT sham. ***P<0.001 versus WT sham, ^#P<0.05 versus WT I/R. WT sham: n=9, WT I/R: n=12, A2^−/− I/R: n=7, A2^−/− sham: n=6. Data are presented as mean±S.E.M.