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. 2016 Nov 24;7(11):e2487. doi: 10.1038/cddis.2016.388

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Adiponectin reduced serum FFA and prevented ER stress in adipose tissue. In all, 1 mg/kg recombinant murine adiponectin was injected into the tail vein of mice with or without ER stress. Injection of saline was used as control. n=6 for each treatment. (a) Serum adiponectin concentration. (b) Relative mRNA levels of AdipoR1 and PPARα. (c) The iWAT weight of mice. (d) Serum FFA concentration. (e) GTT of mice. (f) Relative mRNA levels of GRP78, Chop and ATF2. Values are means±S.D. *P<0.05 compared with the saline control