Figure 5.

PAR2 expression in the human endocrine pancreas. Serial sections (left versus right columns) from a human pancreas stained for PAR2 (white in c-j and o–r), glucagon (green in a, b, e-j and s-v), insulin (red in a, e, g, h, k and l) and somatostatin (red in b, f, i, j, m and n). As in the mouse (Figures 4 and 6), the expression of PAR2 in the islet cells was highest in δ-cells (surrounded by yellow dashed line in h, j, l, n, p, r, t, v), intermediate in β-cells, and lowest in α-cells (surrounded by green dashed line in h, j, l, n, p, r, t and v). (a-f) show low power views (scale bars=75 μm), whereas (g-v) show high-power views of the areas in the yellow squares (scale bars=10 μm)